Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Gut-Brain Axis and IBD: Latest Research Insights
This week we explore groundbreaking research on the gut-brain axis, IBD management, and novel therapeutic approaches, featuring studies on gut motility genetics, fecal microbiota transplantation for depression, and the latest in UC treatment guidelines.
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Bibliografia
1. Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility.
Authors: Díaz-Muñoz C, Bozzarelli I, Lopera-Maya EA, et al.
Journal: Gut
PMID: 41558814
DOI: 10.1136/gutjnl-2025-337059
2. Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Authors: Li J, Wang Y, Li R, et al.
Journal: Cell host & microbe
PMID: 42309058
DOI: 10.1016/j.chom.2026.05.017
3. An international multidisciplinary consensus statement on laparoscopic liver biopsy.
Authors: Lei SY, Han Y, Rockey DC, et al.
Journal: Cell reports. Medicine
PMID: 42173098
DOI: 10.1016/j.xcrm.2026.102831
4. Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery.
Authors: Sabajo CR, Ten Cate DWG, van Grinsven S, et al.
Journal: JAMA surgery
PMID: 42160080
DOI: 10.1001/jamasurg.2026.1519
5. Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.
Authors: Reinisch W, Atreya R, Rieder F, et al.
Journal: The American journal of gastroenterology
PMID: 41504318
DOI: 10.14309/ajg.0000000000003906
6. Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn's and Colitis (PREdiCCt) prospective cohort study.
Authors: Constantine-Cooke N, Gros B, Plevris N, et al.
Journal: Gut
PMID: 41554630
DOI: 10.1136/gutjnl-2025-337846
7. From inflammation to malignancy: the dynamic evolution of cancer-associated fibroblasts in IBD-CRC.
Authors: Naito N, Kasashima H, Fukuoka T, et al.
Journal: Neoplasia (New York, N.Y.)
PMID: 42019096
DOI: 10.1016/j.neo.2026.101310
8. Constipation with bloating: a clinical approach to evaluation and management.
Authors: Cangemi DJ, Laitman AP, Faiman O, et al.
Journal: Annals of medicine
PMID: 42319080
DOI: 10.1080/07853890.2026.2684172
9. Gut microbiota metabolites in inflammatory bowel disease: advances in mechanistic insights.
Authors: Liang Y, Zhou Y, Luo P, et al.
Journal: Frontiers in immunology
PMID: 42358979
DOI: 10.3389/fimmu.2026.1827426
10. Mirikizumab as Induction and Maintenance Therapy in Chinese Patients with Ulcerative Colitis: A Subpopulation Analysis of the Randomized, Global Phase 3 LUCENT-1 and LUCENT-2 Trials.
Authors: Ran Z, Chen Y, Miao Y, et al.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
PMID: 42120652
DOI: 10.1007/s40259-026-00776-y
Authors: Díaz-Muñoz C, Bozzarelli I, Lopera-Maya EA, et al.
Journal: Gut
PMID: 41558814
DOI: 10.1136/gutjnl-2025-337059
2. Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Authors: Li J, Wang Y, Li R, et al.
Journal: Cell host & microbe
PMID: 42309058
DOI: 10.1016/j.chom.2026.05.017
3. An international multidisciplinary consensus statement on laparoscopic liver biopsy.
Authors: Lei SY, Han Y, Rockey DC, et al.
Journal: Cell reports. Medicine
PMID: 42173098
DOI: 10.1016/j.xcrm.2026.102831
4. Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery.
Authors: Sabajo CR, Ten Cate DWG, van Grinsven S, et al.
Journal: JAMA surgery
PMID: 42160080
DOI: 10.1001/jamasurg.2026.1519
5. Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.
Authors: Reinisch W, Atreya R, Rieder F, et al.
Journal: The American journal of gastroenterology
PMID: 41504318
DOI: 10.14309/ajg.0000000000003906
6. Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn's and Colitis (PREdiCCt) prospective cohort study.
Authors: Constantine-Cooke N, Gros B, Plevris N, et al.
Journal: Gut
PMID: 41554630
DOI: 10.1136/gutjnl-2025-337846
7. From inflammation to malignancy: the dynamic evolution of cancer-associated fibroblasts in IBD-CRC.
Authors: Naito N, Kasashima H, Fukuoka T, et al.
Journal: Neoplasia (New York, N.Y.)
PMID: 42019096
DOI: 10.1016/j.neo.2026.101310
8. Constipation with bloating: a clinical approach to evaluation and management.
Authors: Cangemi DJ, Laitman AP, Faiman O, et al.
Journal: Annals of medicine
PMID: 42319080
DOI: 10.1080/07853890.2026.2684172
9. Gut microbiota metabolites in inflammatory bowel disease: advances in mechanistic insights.
Authors: Liang Y, Zhou Y, Luo P, et al.
Journal: Frontiers in immunology
PMID: 42358979
DOI: 10.3389/fimmu.2026.1827426
10. Mirikizumab as Induction and Maintenance Therapy in Chinese Patients with Ulcerative Colitis: A Subpopulation Analysis of the Randomized, Global Phase 3 LUCENT-1 and LUCENT-2 Trials.
Authors: Ran Z, Chen Y, Miao Y, et al.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
PMID: 42120652
DOI: 10.1007/s40259-026-00776-y
