Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Gut-Brain Axis and IBD: Latest Research Insights
This week we explore groundbreaking research on the gut-brain axis, IBD management, and novel therapeutic approaches, featuring studies on gut motility genetics, fecal microbiota transplantation for depression, and the latest in UC treatment guidelines.
Bibliography
1. Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility.
Authors: Díaz-Muñoz C, Bozzarelli I, Lopera-Maya EA, et al.
Journal: Gut
PMID: 41558814
DOI: 10.1136/gutjnl-2025-337059
2. Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Authors: Li J, Wang Y, Li R, et al.
Journal: Cell host & microbe
PMID: 42309058
DOI: 10.1016/j.chom.2026.05.017
3. An international multidisciplinary consensus statement on laparoscopic liver biopsy.
Authors: Lei SY, Han Y, Rockey DC, et al.
Journal: Cell reports. Medicine
PMID: 42173098
DOI: 10.1016/j.xcrm.2026.102831
4. Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery.
Authors: Sabajo CR, Ten Cate DWG, van Grinsven S, et al.
Journal: JAMA surgery
PMID: 42160080
DOI: 10.1001/jamasurg.2026.1519
5. Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.
Authors: Reinisch W, Atreya R, Rieder F, et al.
Journal: The American journal of gastroenterology
PMID: 41504318
DOI: 10.14309/ajg.0000000000003906
6. Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn's and Colitis (PREdiCCt) prospective cohort study.
Authors: Constantine-Cooke N, Gros B, Plevris N, et al.
Journal: Gut
PMID: 41554630
DOI: 10.1136/gutjnl-2025-337846
7. From inflammation to malignancy: the dynamic evolution of cancer-associated fibroblasts in IBD-CRC.
Authors: Naito N, Kasashima H, Fukuoka T, et al.
Journal: Neoplasia (New York, N.Y.)
PMID: 42019096
DOI: 10.1016/j.neo.2026.101310
8. Constipation with bloating: a clinical approach to evaluation and management.
Authors: Cangemi DJ, Laitman AP, Faiman O, et al.
Journal: Annals of medicine
PMID: 42319080
DOI: 10.1080/07853890.2026.2684172
9. Gut microbiota metabolites in inflammatory bowel disease: advances in mechanistic insights.
Authors: Liang Y, Zhou Y, Luo P, et al.
Journal: Frontiers in immunology
PMID: 42358979
DOI: 10.3389/fimmu.2026.1827426
10. Mirikizumab as Induction and Maintenance Therapy in Chinese Patients with Ulcerative Colitis: A Subpopulation Analysis of the Randomized, Global Phase 3 LUCENT-1 and LUCENT-2 Trials.
Authors: Ran Z, Chen Y, Miao Y, et al.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
PMID: 42120652
DOI: 10.1007/s40259-026-00776-y
Authors: Díaz-Muñoz C, Bozzarelli I, Lopera-Maya EA, et al.
Journal: Gut
PMID: 41558814
DOI: 10.1136/gutjnl-2025-337059
2. Adjunctive fecal microbiota transplantation for major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Authors: Li J, Wang Y, Li R, et al.
Journal: Cell host & microbe
PMID: 42309058
DOI: 10.1016/j.chom.2026.05.017
3. An international multidisciplinary consensus statement on laparoscopic liver biopsy.
Authors: Lei SY, Han Y, Rockey DC, et al.
Journal: Cell reports. Medicine
PMID: 42173098
DOI: 10.1016/j.xcrm.2026.102831
4. Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery.
Authors: Sabajo CR, Ten Cate DWG, van Grinsven S, et al.
Journal: JAMA surgery
PMID: 42160080
DOI: 10.1001/jamasurg.2026.1519
5. Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.
Authors: Reinisch W, Atreya R, Rieder F, et al.
Journal: The American journal of gastroenterology
PMID: 41504318
DOI: 10.14309/ajg.0000000000003906
6. Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn's and Colitis (PREdiCCt) prospective cohort study.
Authors: Constantine-Cooke N, Gros B, Plevris N, et al.
Journal: Gut
PMID: 41554630
DOI: 10.1136/gutjnl-2025-337846
7. From inflammation to malignancy: the dynamic evolution of cancer-associated fibroblasts in IBD-CRC.
Authors: Naito N, Kasashima H, Fukuoka T, et al.
Journal: Neoplasia (New York, N.Y.)
PMID: 42019096
DOI: 10.1016/j.neo.2026.101310
8. Constipation with bloating: a clinical approach to evaluation and management.
Authors: Cangemi DJ, Laitman AP, Faiman O, et al.
Journal: Annals of medicine
PMID: 42319080
DOI: 10.1080/07853890.2026.2684172
9. Gut microbiota metabolites in inflammatory bowel disease: advances in mechanistic insights.
Authors: Liang Y, Zhou Y, Luo P, et al.
Journal: Frontiers in immunology
PMID: 42358979
DOI: 10.3389/fimmu.2026.1827426
10. Mirikizumab as Induction and Maintenance Therapy in Chinese Patients with Ulcerative Colitis: A Subpopulation Analysis of the Randomized, Global Phase 3 LUCENT-1 and LUCENT-2 Trials.
Authors: Ran Z, Chen Y, Miao Y, et al.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
PMID: 42120652
DOI: 10.1007/s40259-026-00776-y
