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PCOS Unlocked: From Oxidative Stress to Brain Pathways

Advancements in Gynecology: A Weekly Review

Ginecologia e Ostetricia

PCOS Unlocked: From Oxidative Stress to Brain Pathways

This episode explores groundbreaking research that’s reshaping how we understand polycystic ovary syndrome (PCOS) — from oxidative stress and cell death mechanisms to brain-centered origins and novel therapeutic targets.

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Bibliography

- Liu H, et al. Reactive oxygen species in PCOS: pathogenesis and therapeutic opportunities. Redox Biol. 2025;85:103776.


- Li YY, et al. Fundamental mechanisms of cell death in PCOS. Biochem Biophys Rep. 2025;43:102043.


- Zeng W, et al. Metformin in PCOS: multi-stage therapeutic mechanisms. Front Pharmacol. 2025;16:1654372.


- Seyedi SA, et al. Lipid Accumulation Product Index as a marker of metabolic syndrome in PCOS: meta-analysis. Endocrinol Diabetes Metab. 2025;8(5):e70078.


- Zaborowska L, et al. Uterine morphology and anomalies in PCOS: systematic review & meta-analysis. Hum Reprod. 2025;40(9):1629-1642.


- Vieyra E, et al. Hypothalamic nuclei and regulation of PCOS: clinical, metabolic, and endocrine aspects. Molecules. 2025;30(16):3407.


- Zaborowska L, et al. Functional and structural uterine changes in PCOS. Int J Mol Sci. 2025;26(16):7921.


- Alkhatib M, et al. Semaglutide’s multifaceted effects: broad therapeutic applications. Future Sci OA. 2025;11(1):2483607.


- Chen D, et al. Post-translational modifications in folliculogenesis and ovarian pathologies. Cells. 2025;14(16):1292.


- Moharir SR, et al. SIRT1 activators for PCOS treatment: a new frontier. Biomed Pharmacother. 2025;190:118361.
 

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