Rethinking Diabetes: A Weekly Review
Malattie Metaboliche e Diabetologia
Advances in Diabetes Management and Metabolic Research
This week's episode covers groundbreaking research in diabetes management, including cardiovascular protection with GLP-1 RAs, novel insulin therapies, gender differences in hypoglycemia, and advances in diabetic kidney disease treatment.
Bibliography
1. Anthropometric characteristics at birth and growth outcome in patients with X-linked hypophosphatemia treated with oral phosphate and active vitamin D.
Authors: Przygodda S, Brieger LC, Bohlen AV, et al.
Journal: Pediatric nephrology (Berlin, Germany), 2026 Sep
PMID: 41963716
DOI: 10.1007/s00467-026-07271-0
2. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Authors: Kristensen SL, Rørth R, Jhund PS, et al.
Journal: The lancet. Diabetes & endocrinology, 2019 Oct
PMID: 31422062
DOI: 10.1016/S2213-8587(19)30249-9
3. A validated, modifiable proteomic score from the EXSCEL trial predicts cardiovascular events in diabetes.
Authors: Corey KM, Nguyen M, Mi MY, et al.
Journal: JCI insight, 2026 Aug 24
PMID: 42390946
DOI: 10.1172/jci.insight.204463
4. Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.
Authors: Suntornlohanakul O, Reimondo G, Ghislieri M, et al.
Journal: The lancet. Diabetes & endocrinology, 2026 Sep
PMID: 42413529
DOI: 10.1016/S2213-8587(26)00098-7
5. Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once-Weekly Basal Insulin Icodec.
Authors: Pieber TR, Bajaj HS, Fluhr G, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387301
DOI: 10.1111/dom.71050
6. Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study.
Authors: McCarthy A, Kent G, Thomas J, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42322375
DOI: 10.1007/s00125-026-06775-6
7. Efficacy and Safety of Intensifying Once-Weekly Insulin Icodec Treatment With Once-Weekly Semaglutide in Adults With Type 2 Diabetes: A Single-Arm, Open-Label, Treat-to-Target, Phase 3b Trial (ONWARDS 8).
Authors: Strojek K, Liebl A, Mumbaikar NN, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387310
DOI: 10.1111/dom.71049
8. Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes.
Authors: Filippatos G, Anker SD, Agarwal R, et al.
Journal: Circulation, 2021 Feb 9
PMID: 33198491
DOI: 10.1161/CIRCULATIONAHA.120.051898
9. Islet ultrastructure: past achievements and future directions.
Authors: Müller A, Aurrecoechea Duran S, Santos PI, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42426419
DOI: 10.1007/s00125-026-06782-7
Authors: Przygodda S, Brieger LC, Bohlen AV, et al.
Journal: Pediatric nephrology (Berlin, Germany), 2026 Sep
PMID: 41963716
DOI: 10.1007/s00467-026-07271-0
2. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.
Authors: Kristensen SL, Rørth R, Jhund PS, et al.
Journal: The lancet. Diabetes & endocrinology, 2019 Oct
PMID: 31422062
DOI: 10.1016/S2213-8587(19)30249-9
3. A validated, modifiable proteomic score from the EXSCEL trial predicts cardiovascular events in diabetes.
Authors: Corey KM, Nguyen M, Mi MY, et al.
Journal: JCI insight, 2026 Aug 24
PMID: 42390946
DOI: 10.1172/jci.insight.204463
4. Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.
Authors: Suntornlohanakul O, Reimondo G, Ghislieri M, et al.
Journal: The lancet. Diabetes & endocrinology, 2026 Sep
PMID: 42413529
DOI: 10.1016/S2213-8587(26)00098-7
5. Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once-Weekly Basal Insulin Icodec.
Authors: Pieber TR, Bajaj HS, Fluhr G, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387301
DOI: 10.1111/dom.71050
6. Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study.
Authors: McCarthy A, Kent G, Thomas J, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42322375
DOI: 10.1007/s00125-026-06775-6
7. Efficacy and Safety of Intensifying Once-Weekly Insulin Icodec Treatment With Once-Weekly Semaglutide in Adults With Type 2 Diabetes: A Single-Arm, Open-Label, Treat-to-Target, Phase 3b Trial (ONWARDS 8).
Authors: Strojek K, Liebl A, Mumbaikar NN, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387310
DOI: 10.1111/dom.71049
8. Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes.
Authors: Filippatos G, Anker SD, Agarwal R, et al.
Journal: Circulation, 2021 Feb 9
PMID: 33198491
DOI: 10.1161/CIRCULATIONAHA.120.051898
9. Islet ultrastructure: past achievements and future directions.
Authors: Müller A, Aurrecoechea Duran S, Santos PI, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42426419
DOI: 10.1007/s00125-026-06782-7
