Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Gastroenterology Insights: Advances in Asthma, UC, and Constipation Management
This week we discuss groundbreaking research on tezepelumab for asthma, new AGA guidelines for ulcerative colitis and chronic constipation, atrophic gastritis management, and preterm infant nutrition.
Bibliography
1. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Authors: Walsh TS, Parker RA, Aitken LM, et al.
Journal: JAMA
PMID: 40388916
DOI: 10.1001/jama.2025.7200
2. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Oki R, Izumi Y, Fujita K, et al.
Journal: JAMA neurology
PMID: 35532908
DOI: 10.1001/jamaneurol.2022.0901
3. Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Authors: Li HK, Rombach I, Zambellas R, et al.
Journal: The New England journal of medicine
PMID: 30699315
DOI: 10.1056/NEJMoa1710926
4. Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis.
Authors: Weidinger S, Blauvelt A, Papp KA, et al.
Journal: The Journal of allergy and clinical immunology
PMID: 39522654
DOI: 10.1016/j.jaci.2024.10.031
5. NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma.
Authors: Menzies-Gow A, Colice G, Griffiths JM, et al.
Journal: Respiratory research
PMID: 33050934
DOI: 10.1186/s12931-020-01526-6
Authors: Walsh TS, Parker RA, Aitken LM, et al.
Journal: JAMA
PMID: 40388916
DOI: 10.1001/jama.2025.7200
2. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Oki R, Izumi Y, Fujita K, et al.
Journal: JAMA neurology
PMID: 35532908
DOI: 10.1001/jamaneurol.2022.0901
3. Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Authors: Li HK, Rombach I, Zambellas R, et al.
Journal: The New England journal of medicine
PMID: 30699315
DOI: 10.1056/NEJMoa1710926
4. Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis.
Authors: Weidinger S, Blauvelt A, Papp KA, et al.
Journal: The Journal of allergy and clinical immunology
PMID: 39522654
DOI: 10.1016/j.jaci.2024.10.031
5. NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma.
Authors: Menzies-Gow A, Colice G, Griffiths JM, et al.
Journal: Respiratory research
PMID: 33050934
DOI: 10.1186/s12931-020-01526-6
