Advancements in Gynecology: A Weekly Review
Ginecologia e Ostetricia
Gynecology and Obstetrics Insights: Advances in Cancer Treatment and Surgical Approaches
This week we discuss groundbreaking research in gynecologic oncology including pembrolizumab for endometrial cancer and trastuzumab deruxtecan for HER2+ breast cancer with brain metastases, plus practice-changing data on hysterectomy approaches in cervical cancer.
Bibliography
1. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Authors: Walsh TS, Parker RA, Aitken LM, et al.
Journal: JAMA
PMID: 40388916
DOI: 10.1001/jama.2025.7200
2. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Oki R, Izumi Y, Fujita K, et al.
Journal: JAMA neurology
PMID: 35532908
DOI: 10.1001/jamaneurol.2022.0901
3. Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Authors: Li HK, Rombach I, Zambellas R, et al.
Journal: The New England journal of medicine
PMID: 30699315
DOI: 10.1056/NEJMoa1710926
4. Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis.
Authors: Weidinger S, Blauvelt A, Papp KA, et al.
Journal: The Journal of allergy and clinical immunology
PMID: 39522654
DOI: 10.1016/j.jaci.2024.10.031
5. NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma.
Authors: Menzies-Gow A, Colice G, Griffiths JM, et al.
Journal: Respiratory research
PMID: 33050934
DOI: 10.1186/s12931-020-01526-6
Authors: Walsh TS, Parker RA, Aitken LM, et al.
Journal: JAMA
PMID: 40388916
DOI: 10.1001/jama.2025.7200
2. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Oki R, Izumi Y, Fujita K, et al.
Journal: JAMA neurology
PMID: 35532908
DOI: 10.1001/jamaneurol.2022.0901
3. Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Authors: Li HK, Rombach I, Zambellas R, et al.
Journal: The New England journal of medicine
PMID: 30699315
DOI: 10.1056/NEJMoa1710926
4. Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis.
Authors: Weidinger S, Blauvelt A, Papp KA, et al.
Journal: The Journal of allergy and clinical immunology
PMID: 39522654
DOI: 10.1016/j.jaci.2024.10.031
5. NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma.
Authors: Menzies-Gow A, Colice G, Griffiths JM, et al.
Journal: Respiratory research
PMID: 33050934
DOI: 10.1186/s12931-020-01526-6
