Pediatric Frontiers: Weekly Insights
Pediatria
The NEC Revolution: When AI Meets the Microbiome
Necrotizing enterocolitis (NEC) remains one of the most devastating conditions in premature infants — but a new wave of research is changing everything. In this episode, Pediatric Frontiers explores the cutting-edge science reshaping prevention and care: from bacteriophage-driven microbiome insights to AI systems predicting NEC before symptoms appear, and feeding trials optimizing milk temperature and probiotics.
Discover how global collaboration is turning decades of frustration into a future of hope.
Bibliography
- Jawale N. et al. The Nonbacterial Infant Microbiome and Necrotizing Enterocolitis. Am J Perinatol. 2025;42(14):1836–1845. doi:10.1055/a-2549-6551
- Sha C. et al. Necrotizing Enterocolitis: What's New and What's Next? Int J Mol Sci. 2025;26(19):9660. doi:10.3390/ijms26199660
- Ishiyama A. et al. Toll-like Receptor 4-Mediated Pathophysiology and Therapeutic Insights in NEC. Biomedicines. 2025;13(9):2288. doi:10.3390/biomedicines13092288
- Liu X. et al. Milk Temperature and NEC Risk in Very Preterm Infants: Study Protocol for a Randomized Trial. BMC Pediatr. 2025;25(1):782. doi:10.1186/s12887-025-06159-6
- Suntharalingam H. et al. Exclusive Human Milk for Infants with Gastroschisis: A Systematic Review and Meta-Analysis. J Neonatal Perinatal Med. 2025. doi:10.1177/19345798251384981
- Barrett R. et al. Transforming Neonatal Care Through Informatics: Artificial Intelligence and Implementation Considerations. Semin Perinatol. 2025. doi:10.1016/j.semperi.2025.152144
- Embleton N.D. et al. Probiotic Supplementation — Does It Prevent or Cause Neonatal Sepsis? Semin Fetal Neonatal Med. 2025. doi:10.1016/j.siny.2025.101668
- Serra G. et al. NEC Due to Mesenteric Artery Thrombosis in Craniofrontonasal Dysplasia: Casual or Causal? J Clin Med. 2025;14(19):7055. doi:10.3390/jcm14197055
- Lina S. et al. Crohn-like Perianastomotic Ulcerations After Neonatal NEC Surgery: A Case of Successful Anti-TNF Therapy. BMC Pediatr. 2025;25(1):747. doi:10.1186/s12887-025-06140-3
- Rochow N. et al. Freeze-Dried Donor Milk for Fortification of Mother’s Own Milk in Preterm Infants: A Preliminary Observational Study. Nutrients. 2025;17(19):3057. doi:10.3390/nu17193057
