Rethinking Diabetes: A Weekly Review
Malattie Metaboliche e Diabetologia
Diabetes Management Breakthroughs: From Medications to Microbiome
This week's episode explores groundbreaking diabetes research, from cardiovascular benefits of newer medications to innovative approaches like cold exposure therapy and intraperitoneal insulin delivery. We also examine personalized medicine through diabetes subtypes and probiotic responses.
Bibliography
1. Effect of Medications for Type 2 Diabetes on Cardiovascular Events and Mortality: A Comprehensive Pairwise and Network Meta-Analysis.
Authors: Silverii GA, Velardi V, Marinelli C, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42530338
DOI: 10.1111/dom.71128
2. Acute mild cold exposure with shivering reduces 24 h glucose levels in individuals with type 2 diabetes but not prediabetes.
Authors: Hashim D, Jörgensen JA, van de Weijer T, et al.
Journal: Diabetologia, 2026 Oct
PMID: 42474505
DOI: 10.1007/s00125-026-06809-z
3. Continuous Intraperitoneal Insulin Infusion for People With Type 1 Diabetes: A Literature Review and International Position Statement.
Authors: Oliver N, Gehr B, Lal R, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42426563
DOI: 10.1111/dom.71054
4. Efficacy and Hypoglycaemia Outcomes With Once-Weekly IcoSema Versus Comparators in Individuals With Type 2 Diabetes by Kidney and Liver Function: A Post Hoc Analysis of the COMBINE 1-3 Trials.
Authors: Ji L, Andersen JD, Benamar M, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42557064
DOI: 10.1111/dom.70895
5. Intensity matters: high-intensity interval resistance exercise induces greater immune activation than low-intensity resistance exercise 45 min post-workout.
Authors: Fabritius F, Rißmayer M, Ringleb M, et al.
Journal: European journal of applied physiology, 2026 Oct
PMID: 42461394
DOI: 10.1007/s00421-026-06337-z
6. Type 2 diabetes subtypes for precision medicine: methodological challenges and alternative prediction-based approaches.
Authors: Mori T, Herder C, Cardoso P, et al.
Journal: Diabetologia, 2026 Oct
PMID: 42502138
DOI: 10.1007/s00125-026-06802-6
7. Increased Intake of Foods Providing Alpha-Linolenic Acid Modifies Nutritional and Non-nutritional Characteristics of Breast Milk: A Randomized Clinical Trial.
Authors: Thibault R, Boudry G, Legrand P, et al.
Journal: The Journal of nutrition, 2026 Oct
PMID: 42607835
DOI: 10.1016/j.tjnut.2026.101787
8. Continuous glucose monitoring after discontinuation of incretin-based obesity pharmacotherapy: indirect evidence and a research framework for metabolic stability and weight maintenance.
Authors: Koceva A, Janez A, Jensterle M
Journal: Frontiers in endocrinology, 2026
PMID: 42865881
DOI: 10.3389/fendo.2026.1892632
9. Effects of age, sex, and renal function on bowel movement-improving effects of Bifidobacterium bifidum G9-1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study.
Authors: Ikeda F, Sato J, Yoshii H, et al.
Journal: Journal of diabetes investigation, 2026 Oct
PMID: 42504070
DOI: 10.1111/jdi.70406
10. A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra-Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI.
Authors: Svehlikova E, Gatschelhofer C, Lackner B, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42530378
DOI: 10.1111/dom.71150
Authors: Silverii GA, Velardi V, Marinelli C, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42530338
DOI: 10.1111/dom.71128
2. Acute mild cold exposure with shivering reduces 24 h glucose levels in individuals with type 2 diabetes but not prediabetes.
Authors: Hashim D, Jörgensen JA, van de Weijer T, et al.
Journal: Diabetologia, 2026 Oct
PMID: 42474505
DOI: 10.1007/s00125-026-06809-z
3. Continuous Intraperitoneal Insulin Infusion for People With Type 1 Diabetes: A Literature Review and International Position Statement.
Authors: Oliver N, Gehr B, Lal R, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42426563
DOI: 10.1111/dom.71054
4. Efficacy and Hypoglycaemia Outcomes With Once-Weekly IcoSema Versus Comparators in Individuals With Type 2 Diabetes by Kidney and Liver Function: A Post Hoc Analysis of the COMBINE 1-3 Trials.
Authors: Ji L, Andersen JD, Benamar M, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42557064
DOI: 10.1111/dom.70895
5. Intensity matters: high-intensity interval resistance exercise induces greater immune activation than low-intensity resistance exercise 45 min post-workout.
Authors: Fabritius F, Rißmayer M, Ringleb M, et al.
Journal: European journal of applied physiology, 2026 Oct
PMID: 42461394
DOI: 10.1007/s00421-026-06337-z
6. Type 2 diabetes subtypes for precision medicine: methodological challenges and alternative prediction-based approaches.
Authors: Mori T, Herder C, Cardoso P, et al.
Journal: Diabetologia, 2026 Oct
PMID: 42502138
DOI: 10.1007/s00125-026-06802-6
7. Increased Intake of Foods Providing Alpha-Linolenic Acid Modifies Nutritional and Non-nutritional Characteristics of Breast Milk: A Randomized Clinical Trial.
Authors: Thibault R, Boudry G, Legrand P, et al.
Journal: The Journal of nutrition, 2026 Oct
PMID: 42607835
DOI: 10.1016/j.tjnut.2026.101787
8. Continuous glucose monitoring after discontinuation of incretin-based obesity pharmacotherapy: indirect evidence and a research framework for metabolic stability and weight maintenance.
Authors: Koceva A, Janez A, Jensterle M
Journal: Frontiers in endocrinology, 2026
PMID: 42865881
DOI: 10.3389/fendo.2026.1892632
9. Effects of age, sex, and renal function on bowel movement-improving effects of Bifidobacterium bifidum G9-1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study.
Authors: Ikeda F, Sato J, Yoshii H, et al.
Journal: Journal of diabetes investigation, 2026 Oct
PMID: 42504070
DOI: 10.1111/jdi.70406
10. A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra-Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI.
Authors: Svehlikova E, Gatschelhofer C, Lackner B, et al.
Journal: Diabetes, obesity & metabolism, 2026 Oct
PMID: 42530378
DOI: 10.1111/dom.71150
